Single-cell mutation analysis of clonal evolution in myeloid ...
2020年10月28日 · We mapped clonal trajectories for each sample and uncovered combinations of mutations that synergized to promote clonal expansion and dominance. Finally, we combined …
Nature | 髓系恶性肿瘤克隆进化的单细胞突变分析 - 知乎
近日，来自美国的研究团队Linde A. Miles等人在《Nature》上发表了一篇名为“Single-cell mutation analysis of clonal evolution in myeloid malignancies”的文章。文中通过对123例患者的146份样 …
Nature | 单细胞DNA测序揭示髓系恶性肿瘤的克隆进化 - 知乎
近日，来自美国 纪念斯隆-凯特琳癌症中心 的Ross L. Levine教授在Nature发表研究 Single-cell mutation analysis of clonal evolution in myeloid malignancies，该研究利用单细胞DNA测序技 …
The evolutionary theory of cancer: challenges and potential …
2024年9月10日 · An explanatory mechanism of cell diversification that has gained traction in the twenty-first century is clonal evolution: cancer cells diversify through the accumulation of …
Clonal evolution and clinical correlates of somatic mutations in ...
2014年4月3日 · We used targeted next-generation sequencing (NGS) of 104 genes to detect somatic mutations in a cohort of 197 MPN patients and followed clonal evolution and the …
Clonal evolution of acute myeloid leukemia revealed by high ... - Nature
2020年10月21日 · The single-cell data reveals cell-level mutation co-occurrence and enables reconstruction of mutational histories characterized by linear and branching patterns of clonal …
Clonal Evolution of Multiple Myeloma—Clinical and Diagnostic ...
More and more data suggest that tumor progression, dissemination, and relapse in MM is driven by clonal evolution, a process of natural selection facilitating tumor plasticity and the ability to …
Single-cell mutation analysis of clonal evolution in myeloid ...
We mapped clonal trajectories for each sample and uncovered combinations of mutations that synergized to promote clonal expansion and dominance. Finally, we combined protein …
Clonal Heterogeneity and Tumor Evolution: Past, Present, and …
2017年2月9日 · Here, we review data and technologies that have revealed intra-tumor heterogeneity across cancer types and the dynamics, constraints, and contingencies inherent …
Clonal Evolution in Cancer - Mission Bio
There are two main models of clonal evolution in cancer: linear and branched. 1 In linear evolution, each new driver mutation enables a selective sweep, in which the mutant cell — …
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