A humanized mouse or a humanized mouse model is one that has been xenotransplanted with human cells and/or engineered to express human gene products, so as to be utilized for gaining relevant insights in the in vivo context for understanding of human …

2020年3月6日 · 目前根据移植入小鼠的人免疫细胞类型， 免疫系统人源化小鼠 主要可分为 huPBMC (Human peripheral blood mononu. 作为肿瘤治疗研究中最具发展潜力的领域，肿瘤免疫疗法目前已在多种恶性肿瘤的临床上展现出良好的治疗效果，然而由于药物靶点及其本身的局限性，有很多临床患者仍不能从已有的CAR-T和免疫检查点免疫疗法中获益。 因…

2023年1月12日 · Humanized mouse models of cancer are immunodeficient mice co-engrafted with human tumours and immune cells, and are used in immuno-oncology research with potential for clinical translation.

The humanized mouse model, as a novel experimental animal in biomedical research, was established by the transplantation of human-derived peripheral blood mononuclear cells (PBMCs) or hematopoietic stem cells (HSCs), and this could be identified as foreign tissues by murine innate and adaptive immune systems [6 - 8].

Humanized NSG mice are a therapeutically translational platform for the evaluation of human immune cells in vivo, the evaluation of single and combinatorial drug approaches, and the production of predictive data for the clinic. These models can be used in immuno-oncology applications, stem cell biology, and therapeutic efficacy/toxicity testing.

2024年12月18日 · Given the unmet need for improved predictive models in immuno-oncology, humanized mouse models which are co-engrafted with both human tumors and immune system components have been employed to investigate novel immunotherapeutics. These models have similarly been utilized to predict immune-related adverse events and to …

We highlight the latest advances in the generation of humanized mouse models, with the aim of providing a guide for their application to immuno-oncology studies with potential for clinical translation.

2019年6月3日 · Humanized mouse models engrafted with human immune cells, human hepatocytes and hepatic stellate cells have been developed that support infection with HBV or HCV and the subsequent...

Humanized mice are permitting significant progress in studies of human infectious disease, cancer, regenerative medicine, graft versus host disease, allergies, and immunity. Ultimately, use of humanized mice may lead to the implementation of truly “personalized” medicine in the clinic.

2012年2月13日 · Humanized mouse models that have received human cells or tissue transplants are extremely useful in basic and applied human disease research. Highly immunodeficient mice, which do not reject...