Wnt signaling pathway - Wikipedia
The canonical Wnt pathway (or Wnt/β-catenin pathway) is the Wnt pathway that causes an accumulation of β-catenin in the cytoplasm and its eventual translocation into the nucleus to act as a transcriptional coactivator of transcription factors that belong to the TCF/LEF family. Without Wnt, β-catenin would not accumulate in the cytoplasm ...
Wnt/β-catenin signalling: function, biological mechanisms, …
2022年1月3日 · In this article, we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research. Finally, we propose challenges and opportunities...
Wnt/β-catenin signaling: components, mechanisms, and diseases
We discuss Wnt ligands, agonists and antagonists and their interactions with Wnt receptors. We also dissect critical events that regulate β-catenin stability from Wnt receptors to the cytoplasmic β-catenin destruction complex, and nuclear machinery that mediates β …
Wnt/β-catenin signalling: function, biological mechanisms, and ...
Wnt/β-catenin signalling is an essential regulator in embryonic development and adult tissue homeostasis. Wnt/β-catenin signalling is initiated by extracellular WNTs and transduced by binding of the ligand to various receptors and coreceptors present at the cell membrane, activating intracellular transcriptional or nontranscriptional responses.
Mechanistic insights into Wnt–β-catenin pathway activation
2 天之前 · Upon Wnt activation, a cascade of signalling events culminates in inhibition of the proteolytic turnover of β-catenin. As a result, newly synthesized β-catenin accumulates in the cytosol and ...
Wnt/β-catenin signalling: function, biological mechanisms, …
2022年1月3日 · The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signalling often leads to various serious diseases, including cancer and non-cancer diseases.
Wnt/β-Catenin Signaling: Components, Mechanisms, and …
We discuss Wnt ligands, agonists, and antagonists, and their interactions with Wnt receptors. We also dissect critical events that regulate β-catenin stability, from Wnt receptors to the cytoplasmic β-catenin destruction complex, and nuclear machinery that mediates β …
The Role of the Wnt/β-catenin Signaling Pathway in Formation …
The Wnt/β-catenin pathway has been identified using in vitro and in vivo approaches to be an important pathway in osteocytes to sense and transduce the signals of mechanical stimuli to bone cells.
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
Here, we describe the core Wnt/β-catenin signaling pathway, how it controls stem cells, and contributes to disease. Finally, we discuss strategies for Wnt-based therapies. Since the initial discovery of the first member of the Wnt family 35 years ago (Nusse and Varmus, 1982), interest in Wnt signaling has steadily risen.
Wnt/β-Catenin Signaling in Development and Disease - Cell Press
2006年11月3日 · Wnt genes encode small secreted proteins that are found in all animal genomes. Wnt signaling is involved in virtually every aspect of embryonic development and also controls homeostatic self-renewal in a number of adult tissues.