Stem-cell niche - Wikipedia
Stem-cell niche refers to a microenvironment, within the specific anatomic location where stem cells are found, which interacts with stem cells to regulate cell fate. [1] The word 'niche' can be in reference to the in vivo or in vitro stem-cell microenvironment.
The Stem Cell Niche: Interactions between Stem Cells and Their ...
Embryonic and adult stem cell research has shown that stem cell fates are controlled by their specialized microenvironment, referred to as the stem cell niche, via direct cell-cell interactions and the molecular signals emitting from the niche.
Stem Cell Niche - an overview | ScienceDirect Topics
Stem cells can be found within the body in a tissue-specific microenvironment called the stem cell niche. The stem cell niche provides cells with both biochemical and physical support to directly influence cellular behavior (Fig. 2). The majority of biochemical cues are the secreted growth factors and cytokines from non-stem cells adjacent or ...
Stem-cell niche - Latest research and news - Nature
2025年1月6日 · A stem-cell niche is an area of a tissue that provides a specific microenvironment, in which stem cells are present in an undifferentiated and self-renewable state.
What does the concept of the stem cell niche really mean today?
Model showing the various cell types comprising the bone marrow hematopoietic stem cell (HSC) niche. The dormant status of HSCs is maintained by transforming growth factor beta (TGF-ß) and thrombopoietin (TPO) produced by nestin+ non-myelinating Schwann cells …
No place like home: anatomy and function of the stem cell niche
By synthesizing data from numerous systems, we can generate a hypothetical 'parts list' for stem cell niches, including: the stem cell itself; stromal support cells that interact directly...
Stem Cells and Their Niches | Science - AAAS
2006年3月31日 · A stem cell niche is an interactive structural unit, organized to facilitate cell-fate decisions in a proper spatiotemporal manner. Key signaling and molecular cross-talk events are patterned to occur in the right place at the right time.
Stem Cell Niche - an overview | ScienceDirect Topics
A stem cell niche is a local microenvironment that directly promotes or protects a population of stem cells. There are two key components to a stem cell niche, the microenvironment and the stem cell, and each of their functions relies on the other.
Tissue Stem Cells: Architects of Their Niches - PMC
Heterologous stem cell niche components include the basement membrane, rich in extracellular matrix and stem cell growth factors, as well as blood vessels, lymphatic capillaries, nerves, stromal, adipose, and a variety of tissue-resident immune cells that function with stem cells to guard against tissue damage and pathogens.
Stem Cell Niche - an overview | ScienceDirect Topics
A stem cell niche provides a specific microenvironment within a tissue in which direct cell–cell interactions and molecular signals either maintain stem cells in the undifferentiated state or promote their differentiation. From: Scientific Principles of Adipose Stem Cells, 2022