A Match Made in Microglia? ApoE and Aβ Click in Lysosomes, …
2024年10月30日 · This Aβ preparation most likely included a mixture of soluble and aggregated Aβ species. Microglial cells internalized the Aβ, promoting aggregation in the presence of ApoE fibrils, and this effect was consistent across BV2, primary, and iPSC-derived microglia, reinforcing the reliability of the findings beyond iPSC models.
In Amyloid and Tangle Models, APOE4 Paralyzes Microglia
2023年10月26日 · Liu and Wang et al. use a microglial-specific knock-in of the human APOE3 or APOE4 alleles in the context of an APOE-/- background, whereas Yin and Rosenzweig et al. specifically deleted only microglial APOE in the context of the humanized knock-in APOE mouse model. Both papers demonstrate conclusively that microglial APOE does contribute to ...
To Be Hale and Hearty, Brain Microglia Need a Healthy Gut
2015年6月5日 · Gut bacteria produce SCFAs as byproducts of fermentation, and they were recently reported as stabilizing immune cells in the colon (Smith et al., 2013). Sure enough, simply adding SCFAs to the drinking water of germ-free mice for four weeks returned microglial shape, maturity, and number almost back to normal.
Over the Span of AD, Roles of Astrocytes and Microglia Change
Because microglia are a diverse lot and make up only a small fraction of cells in the brain, Taga and colleagues developed an automated technique to scan an entire brain section at high resolution, pick out all of the microglia based on their expression of Iba1, and then study other features of the cells (De Jager et al., 2024). In Lisbon, Taga ...
T Cells in the Brain Goad Microglia to Muddle Myelin
2024年6月29日 · CD8+ T cells induce myelin pathology by microglial activation; 4. depletion of T cells or microglia, and blocking interferon or JAK signaling, protects against myelin pathology. We and other groups showed that the removal and modulation of T cells, or T cell-mediated microglia function, rescued many aspects of neurodegeneration, particularly ...
Easing Microglial Brakes Alleviates Amyloid Pathology in Mice
2024年4月11日 · “This is a very interesting paper on microglial mechanisms in AD pathogenesis with implications for potential drug development,” Yadong Huang, University of California, San Francisco, told Alzforum. Leukocyte Ig-like receptors (LILRs) are a group of 11 microglial markers; five activate the cells, five inhibit them.
I’m Open! Exposed Enhancers Reveal Masters of Microglial Moods
2024年8月16日 · For example, in response to a TREM2-activating antibody, IRF3 and E2F emerged as potential master regulators of microglial transitions into interferon-producing and proliferative states, respectively. Yet, after a brief spell of transcriptional upheaval, the cells settled back into their calm, “undosed” state within days.
Long Live the Microglia! Studies Trace Their Lifespans in Mice and ...
2017年8月30日 · Diego Gomez-Nicola of the University of Southampton in the U.K., who had previously reported that microglia turn over rapidly, echoed Butovsky’s concerns about selective labeling of microglial cells, wondering if some microglial subtypes might be more prone to the tamoxifen-induced recombination used to turn on tdTomato (Askew et al., 2017 ...
Most Detailed Look Yet at Activation States of Human Microglia
2020年12月11日 · The paper by Olah et al. evaluates the microglial signature through scRNA-seq analyses of live microglia cells from 10 Alzheimer’s disease (AD), four mild cognitive impairment (MCI) and three temporal lobe epilepsy (TLE) patients and compares these data with microglial signatures from two mouse models of neurodegeneration (CKp25 and 5XFAD ...
Life Without Microglia: Rare Cases of CSF-1R Mutations Paint a …
2019年4月21日 · Microglial progenitors derive from the embryonic yolk sac and migrate into the budding brain early in development. There, their renewal and expansion are driven by colony stimulating factor 1. Some animal studies suggest that the cells are pivotal in supporting myelination of the developing brain, assembling brain circuits, and pruning synapses ...