项目文章|赫捷院士团队揭密肺腺癌 m6A 机制再次登上Nature 子 …
2021年10月8日 · MYC mRNA 的 m6A 修饰可以募集 m6A 识别蛋白 YTHDF1 的结合，从而促进 c-Myc 蛋白的翻译表达，进而提升肿瘤细胞的糖酵解水平和细胞增殖能力，促进肿瘤发生。
WNT/β-catenin-suppressed FTO expression increases m6A of c-Myc mRNA …
2021年5月8日 · Enhanced m 6 A levels on MYC mRNA recruit YTHDF1 binding, which promotes MYC mRNA translation and a subsequent increase in glycolysis and proliferation of tumor …
MYC promotes cancer progression by modulating m6A …
2021年1月11日 · MYC suppresses gene expression by indirectly altering m6A modifications in transcripts of MYC‐repressed genes via ALKBH5 to promote cancer progression.image
An oncopeptide regulates m6A recognition by the m6A reader
2020年4月3日 · RBRP binds to IGF2BP1 and strengthens m6A recognition by IGF2BP1 on RNAs, such as c-Myc mRNA, to increase the mRNA stability and expression of c-Myc, thereby …
MYC promotes cancer progression by modulating m6 A ... - PubMed
2021年3月3日 · Modification of mRNA emerges as a key gene expression regulatory nexus. We sought to determine whether MYC alters mRNA modifications and report here that MYC …
HBXIP promotes gastric cancer via METTL3-mediated MYC mRNA m6A ...
2020年10月13日 · The c-myc proto-oncogene (MYC) N6-methyladenosine (m6A) mRNA methylation was detected by m6A RNA immunoprecipitation and dot-blot assays. Expressions …
WNT/β-catenin-suppressed FTO expression increases m6A of c-Myc mRNA …
2021年5月8日 · Our findings uncovered a critical mechanism of epitranscriptome regulation by Wnt/β-catenin-mediated FTO downregulation and underscored the role of m6A modifications …
MYC-activated RNA N6-methyladenosine reader IGF2BP3 …
2022年2月8日 · In summary, our data illustrated that m6A “reader” IGF2BP3 impacts KPNA2 mRNA stability in an m6A-dependent manner. IGF2BP3 regulates biological functions of NPC …
HBXIP promotes gastric cancer via METTL3-mediated MYC mRNA m6A ...
2020年12月12日 · In this study, we propose an intriguing hypothesis that the hepatitis B X-interacting protein (HBXIP) may function as an oncogene in GC. We harvested 45 GC tissues …
MYC promotes cancer progression by modulating m6A …
2021年1月11日 · Modification of mRNA emerges as a key gene expression regulatory nexus. We sought to determine whether MYC alters mRNA modifications and report here that MYC …