The result of central tolerance is a population of lymphocytes that do not mount immune response towards self-antigens. These cells use their TCR or BCR specificity to recognize foreign antigens, in order to play their specific roles in immune reaction against those antigens.

In this way, tolerance is different from generalised immune suppression (such as that induced by post-transplant drugs like cyclosporine) Central vs. Peripheral Tolerance. Induction of tolerance requires education of both B and T cells, which occurs in both central (bone marrow, thymus) and peripheral (spleen, lymph nodes) lymphoid organs and ...

2020年10月7日 · The first step for tolerance is the central tolerance. In central tolerance, if the T- or B-cell clones possess receptors that identifies self-antigens with high affinity, these cells are deleted before their maturation.

Immune tolerance is critical to prevent the development of autoimmune and inflammatory diseases. There are several mechanisms of tolerance, which can be broadly categorized as either central or peripheral tolerance.

2024年11月23日 · Central tolerance is the mechanism by which newly developing T cells and B cells are rendered non-reactive to self. The concept of central tolerance was proposed in 1959 as part of a general theory of immunity and tolerance.

2023年7月17日 · Central Tolerance. To prevent self-reactive lymphocytes from causing damage, there are various checkpoints that maintain immune tolerance. Central tolerance is the first checkpoint. This is the process by which self-reactive B and T lymphocytes are destroyed in the primary lymphoid organs, namely the bone marrow and the thymus).

Central tolerance is a critical immunological process that occurs during the development of immune cells, primarily in the thymus for T cells and in the bone marrow for B cells. This mechanism ensures that developing lymphocytes do not react against the body's own tissues, thereby preventing autoimmunity and promoting self-tolerance.

Central tolerance is the mechanism by which newly developing T cells and B cells are rendered non-reactive to self. The process is required due to the random generation of receptor specificities that occurs during T cell and B cell differentiation, whereby a proportion of the cells generated are self-reactive (recognise the component self ...

Central tolerance is a process in which autoreactive lymphocytes are selectively prevented from entering the periphery and occurs in either the bone marrow or the thymus.

Central tolerance is a process that occurs in the thymus and bone marrow, where developing immune cells (T and B cells) are taught to distinguish between the body's own cells and foreign cells. Cells that react strongly against self-antigens …