A humanized mouse or a humanized mouse model is one that has been xenotransplanted with human cells and/or engineered to express human gene products, so as to be utilized for …

The humanized mouse model, as a novel experimental animal in biomedical research, was established by the transplantation of human-derived peripheral blood mononuclear cells …

2023年1月12日 · Humanized mouse models of cancer are immunodeficient mice co-engrafted with human tumours and immune cells, and are used in immuno-oncology research with …

Humanized NSG mice are a therapeutically translational platform for the evaluation of human immune cells in vivo, the evaluation of single and combinatorial drug approaches, and the …

We highlight the latest advances in the generation of humanized mouse models, with the aim of providing a guide for their application to immuno-oncology studies with potential for clinical …

Humanized mouse models allow for the study of the cellular mechanisms of rejection of human islets by allogeneic immune responses and provide a preclinical environment to test new …

2019年6月3日 · Humanized mouse models engrafted with human immune cells, human hepatocytes and hepatic stellate cells have been developed that support infection with HBV or …

2019年4月23日 · Researchers increasingly combine these approaches and turn to the targeted genomic humanisation of mice, creating ‘knock-in’ mouse models in which a mouse sequence …

2021年11月21日 · This review discusses the recent advancements and applications of humanized mouse models on human immune system and liver humanization in modeling human …

2023年7月1日 · Humanized mice using immunodeficient mice bearing human tumor and human immune cells represent emerging models to test both efficacy and toxicity of cancer …