In addition to the discovery of human RNA ligases, research has also focused on the mechanisms of tRNA splicing, which is a critical process for the maturation of tRNA molecules. Eukaryotic tRNA ...

RNA splicing is a modification of the nascent ... Here, the authors provide insights into a splicing quality control mechanism. The Gpl1–Gih35 complex binds to the active site of aberrant ...

SEED Therapeutics announced that the U.S. Food and Drug Administration has granted Rare Pediatric Disease and Orphan Drug designations to ...

By targeting key processes like RNA splicing and modification ... Leslie's powerful and robust model systems to nail down this novel mechanism." The UC Irvine scientists partnered with Clotilde ...

"By targeting key processes like RNA splicing and modification ... Leslie's powerful and robust model systems to nail down this novel mechanism," said co-corresponding author Robert Spitale ...

Cambridge, Massachusetts-based Envisagenics focuses on using AI to analyse errors in RNA splicing, a process in which a precursor form of messenger RNA (mRNA) – which is used as a template for ...

In this review of RNA therapies, we paint an overview of what’s going on in a field that is addressing a number of diseases.

This is where DNA and RNA epigenetics come in: a series of mechanisms that act as "markers" on genes, to control their activity without modifying the DNA or RNA sequence itself. Until now ...

A new study from the Kowalinski group at EMBL Grenoble characterized the structure of an important trypanosomal protein ...

The final, formatted version of the article will be published soon. Background. Splicing is the molecular mechanism to produce mature messenger RNA (mRNA) before its translation into protein. It is ...