The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and ...

Kymera Therapeutics, Inc., 500 North Beacon Street, Watertown, Massachusetts. *Corresponding Author: Yogesh K. Chutake, Kymera Therapeutics, Inc., 500 North Beacon ...

Each gene tells a cell to make a specific molecule, but this isn't performed by the DNA itself. Instead, the information is relayed to cellular machinery by a molecule called messenger RNA.

allowing genetic and gene-environment causes of disease to be identified; high-throughput proteomics, which should allow the development of early-detection methods; new tools for the measurement ...

This study presents fundamental insights into overcoming resistance in hormone receptor-positive breast cancer by demonstrating that sustained CDK4/6 inhibitor treatment, either alone or in ...

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

100 and 11 significant genes were identified by support vector machine recursive feature elimination (SVM-RFE ... processed by the combat function of the sva package of the R-4.2.2 package, and ...

Jan. 21, 2025 — Trypanosomes are parasites that cause sleeping sickness, Chagas disease, and various animal diseases. Diagnosis and treatment remain complex and no effective vaccine has been ...

Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. For example, molecular docking is widely used for predicting ...

An ideal immunogenic tumor antigen is crucial to develop an effective cancer immunotherapy. Remarkably, gene fusions have been widely reported to show great potential to produce tumor neoantigens with ...