Burn injuries often leave behind a “stasis zone”, a region of tissue critically important for determining both the severity of the injury and the potential for recovery. To understand the intricate ...

癌症是世界上最难治愈的疾病之一。CAR-T 细胞疗法等一系列癌症免疫疗法的兴起，为癌症治疗带来的新希望。然而，CAR-T 细胞疗法难以持久缓解B细胞恶性肿瘤，这一现象通常可归因于抗原逃逸。例如，CD19 靶向的 CAR-T 细胞疗法中，有 28%-68% 的患者在治疗过程中癌 ...

另一方面，YTHDF2 还可以作为 m6A 读取器，通过破坏其他 mRNA 的稳定性来促进免疫逃避，例如抑制 CD19 和 HLA-DMA/B（MHC II类分子）的表达。 YTHDF2促进 ...

Mandy Cohen, director of the U.S. Centers for Disease Control and Prevention (CDC), pointed to mRNA as a preferred platform for the shot since vaccines can be developed and distributed quickly.

Bioinformatics analysis was performed to explore lncRNA-mRNA networks, leading to the identification of five potential blood biomarkers. Expression analysis was carried out using the GEPIA and GEO ...

In this article, we are going to take a look at where Moderna Inc. (NASDAQ:MRNA) stands against other firms end 2024 stronger with impressive gains. A lackluster trading persisted throughout the ...

S2A). We observed efficient and specific overexpression of Fbxw7 with mRNA and protein levels in BAT, iWAT, and eWAT, but not in non-adipose tissues like liver, gas, and pancreas (Appendix Fig. S2B–E) ...

Instead they end in a conserved stem–loop that interacts with stem–loop binding protein (SLBP), a factor involved in several steps of histone mRNA metabolism: pre-mRNA processing, translation ...

Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, ...

The mRNA cancer vaccine mRNA-4157, developed with Merck (MRK) might have the most promising upside with biopharma awaiting a key Phase 2 interim readout for the melanoma treatment in Q4 2025/H1 2026.