mRNA vaccine developer Moderna (MRNA) is sinking 9% after Goldman Sachs downgraded the shares to Neutral from Buy. Why Goldman Cut Its Rating on MRNA Earlier this month, Moderna reduced its 2025 ...

Bioinformatics analysis was performed to explore lncRNA-mRNA networks, leading to the identification of five potential blood biomarkers. Expression analysis was carried out using the GEPIA and GEO ...

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M. Conacci-Sorrell et al., “Myc-nick: a cytoplasmic cleavage product of Myc that promotes α-tubulin acetylation and cell differentiation,” Cell, 142:480-93, 2010. Free F1000 Evaluation When Maralice ...

Research indicates that METTL3 enhances the expression of PD-L1, a protein that helps tumors evade the immune system, through m6A modification of its mRNA[2][3]. This suggests that targeting ...

In this article, we are going to take a look at where Moderna Inc. (NASDAQ:MRNA) stands against other firms end 2024 stronger with impressive gains. A lackluster trading persisted throughout the ...

Luyuan MOK can travel 80-95 kilometres on a single charge. This 84 kg bike has a battery capacity of 72 volts and a motor power of 800 watts. The front wheel of the bike features a disc brake ...

Figure 4. Interactions between lncRNA and RNA-binding proteins: In the left signaling pathway, lncRNA suppresses the expression of downstream effectors (mRNA) by recruiting RNAbinding proteins; In the ...

另一方面，YTHDF2 还可以作为 m6A 读取器，通过破坏其他 mRNA 的稳定性来促进免疫逃避，例如抑制 CD19 和 HLA-DMA/B（MHC II类分子）的表达。 YTHDF2促进 ...

癌症是世界上最难治愈的疾病之一。CAR-T 细胞疗法等一系列癌症免疫疗法的兴起，为癌症治疗带来的新希望。然而，CAR-T 细胞疗法难以持久缓解B细胞恶性肿瘤，这一现象通常可归因于抗原逃逸。例如，CD19 靶向的 CAR-T 细胞疗法中，有 28%-68% 的患者在治疗过程中癌 ...