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直接RNA测序解锁m6A,中国科学家揭示细胞命运调控新机制
【导读】外转录组修饰,尤其是N6-甲基腺苷(m6A),是基因表达的关键调控因子,影响着RNA的稳定性、剪接和翻译等过程。从Nanopore直接RNA测序(DRS)数据中检测m6A的传统计算方法受限于对实验验证标签的依赖,往往会导致对修饰位点的低估。在 ...
eLife
1 个月
Malaria parasites require a divergent heme oxygenase for apicoplast gene expression and ...
Figure supplement 3. X-ray crystallographic data collection and structure refinement statistics for PfHO. Figure supplement 4. Sequence and structural alignments of PfHO to plant HOs (AtHO1, GmHO1).
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