DNA 聚合酶在 DNA 复制过程中发挥着关键作用，其主要形成磷酸二酯键，以确保遗传信息的准确传递。同时，这一过程还涉及到多种相关的化学反应和酶的协同作用。 1. 磷酸二酯键的形成机制：DNA 聚合酶通过催化脱氧核苷酸之间的反应，将一个脱氧核苷酸的 5'磷酸基团与另一个脱氧核苷酸的 3'羟基相连，从而形成磷酸二酯键。这是 DNA 链延长的基础。 2. 对 ...

T cells play a pivotal role in the immune system by transforming into powerful effector cells that combat pathogens. This transformation requires rapid proliferation, during which DNA replication ...

People genetically susceptible to Huntington's disease often see their movement, mood, and cognition decline slowly over time.

APOBEC enzymes, which normally help fight viral infections by mutating viral DNA, cause repeat expansions and are unusually ...

Researchers at Tufts University revealed a possible molecular mechanism explaining how the DNA repeats are broken and then expanded in the Huntington’s disease gene, pointing to a component of the ...

Nagayama, K. and Hirooka, Y. (2025) Changes in the Mechanical Environment of the Nucleus with Cell Crowding and Its Effects on DNA Damage Resistance. Journal of Biosciences and Medicines, 13, 230-242.

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that ...

Trethera Corporation (“Trethera”), a clinical stage biopharmaceutical company committed to developing novel drugs targeting ...

The following is a summary of “Cobalt chloride-mimicked hepatocyte cell hypoxia induces TREX1 leading to Hepatitis B virus restriction,” published in the January 2025 issue of Infectious Disease by ...