Thanks to the deciphered molecular structure of SAMURI, the researchers can now better answer the question of how the specific interaction of artificial ribozymes with SAM differ from natural ...

Basic Research Guides the Development of New Therapeutic Strategies Knowledge of the structure and function of catalytic RNA is important for improving existing ribozymes and developing new ones.

Basic Research Guides the Development of New Therapeutic Strategies Knowledge of the structure and function of catalytic RNA is important for improving existing ribozymes and developing new ones.

“Our findings could therefore provide new directions for the development of RNA-based therapeutics. It is conceivable that further developed ribozymes could one day be used as drugs themselves.” Dr.

Studies suggest that naturally occurring SAM-binding RNA could be derived from earlier ribozymes that lost their catalytic function during evolution," says Höbartner. Knowledge of the structure ...

Institute of Biophysics of the Czech Academy of Sciences, Kralovopolska 135, 612 00 Brno, Czech Republic ...

The fact that carbamylation is non-enzymatic, makes us believe that it may result in lysine modifications in catalytic or co-factor-binding sites of enzymes. Such modifications could then activate the ...

No large RNA structure database exists that correlates sequence with 3D topology. Successful protein-centric methods like AlphaFold remain unavailable for RNA, creating a critical gap in ...

suggesting that the catalytic activity of Setd2 is crucial for these developmental processes. RNA sequencing and single-cell RNA sequencing analyses of the yolk sac and embryos revealed ...