Thanks to the deciphered molecular structure of SAMURI, the researchers can now better answer the question of how the specific interaction of artificial ribozymes with SAM differ from natural ...

“Our findings could therefore provide new directions for the development of RNA-based therapeutics. It is conceivable that further developed ribozymes could one day be used as drugs themselves.” Dr.

The fact that carbamylation is non-enzymatic, makes us believe that it may result in lysine modifications in catalytic or co-factor-binding sites of enzymes. Such modifications could then activate the ...

No large RNA structure database exists that correlates sequence with 3D topology. Successful protein-centric methods like AlphaFold remain unavailable for RNA, creating a critical gap in ...