Test cases demonstrated that HORNET accurately reconstructed individual RNA conformations, with root-mean-square deviations (a measure of how closely the calculated structure aligns with a ...

Some of the IL-1α-dependent effects appear to be mediated by phosphorylation of p65/RELA or its interactors, with evidence for enhanced recruitment of phosphorylated c-JUN to p65/RELA along with a ...

Direct translocation of RNA with secondary structures using single-molecule electrophoresis through protein nanopores shows significant fluctuations in the measured ionic current, in contrast to ...

Figure 1. The Biogenesis of miRNAs. In the canonical pathway, miRNA biogenesis begins in the nucleus where pri-miRNAs are transcribed by RNA polymerase II. The pri-miRNAs are then cleaved by the ...

Cancer is the second greatest cause of mortality worldwide. According to estimates from the World Health Organization, there were approximately 19 million new cancer cases globally in 2020, resulting ...

Then, on Day 18, ears were collected for further analysis. Data processing of single-cell RNA-sequencing and bulk RNA-sequencing The raw count matrix data from the previously reported single-cell RNA- ...

Sigma 1 receptor (S1R) is a multifunctional, ligand-activated protein located in the membranes of the endoplasmic reticulum (ER). It mediates a variety of neurological disorders, including epilepsy, ...