As shown in the Timeline, large-scale mouse mutagenesis is divided into three phases. In 1997, ENU mutagenesis began with the use of forward genetics, primarily focusing on dominant phenotypes.
1.2.2 Castle, Little, and the founders of mouse genetics The most significant force in early genetic work on the mouse was William Ernest Castle, who directed the Bussey Institute at Harvard ...
The significance of the interspecific cross for mouse genetics cannot be understated: it was the single most important factor in the development of a whole genome linkage map based on molecular ...
Researchers aim to continue studying the role of the X chromosome in brain aging, and whether it can explain people’s risk of brain diseases or memory loss.
X inactivation turns off entire chromosomes, whereas imprinting turns ... was not 100% (only 9 of 24 pregnancies resulted in live mouse pups), the level of success was still dramatic considering ...