Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

The protease assay was carried out in two different buffers. Phosphate buffer (PB) at pH 7.4 was chosen because it is in the range of the pH recommended in the kit protocol for maximizing fluorescence ...

This manuscript describes the identification and characterization of 12 specific phosphomimetic mutations in the recombinant full-length human tau protein that trigger tau to form fibrils. This ...