Figure 4. Interactions between lncRNA and RNA-binding proteins: In the left signaling pathway, lncRNA suppresses the expression of downstream effectors (mRNA) by recruiting RNAbinding proteins; In the ...

癌症是世界上最难治愈的疾病之一。CAR-T 细胞疗法等一系列癌症免疫疗法的兴起，为癌症治疗带来的新希望。然而，CAR-T 细胞疗法难以持久缓解B细胞恶性肿瘤，这一现象通常可归因于抗原逃逸。例如，CD19 靶向的 CAR-T 细胞疗法中，有 28%-68% 的患者在治疗过程中癌 ...

另一方面，YTHDF2 还可以作为 m6A 读取器，通过破坏其他 mRNA 的稳定性来促进免疫逃避，例如抑制 CD19 和 HLA-DMA/B（MHC II类分子）的表达。 YTHDF2促进 ...

Bioinformatics analysis was performed to explore lncRNA-mRNA networks, leading to the identification of five potential blood biomarkers. Expression analysis was carried out using the GEPIA and GEO ...

S2A). We observed efficient and specific overexpression of Fbxw7 with mRNA and protein levels in BAT, iWAT, and eWAT, but not in non-adipose tissues like liver, gas, and pancreas (Appendix Fig. S2B–E) ...

Mandy Cohen, director of the U.S. Centers for Disease Control and Prevention (CDC), pointed to mRNA as a preferred platform for the shot since vaccines can be developed and distributed quickly.

In this article, we are going to take a look at where Moderna Inc. (NASDAQ:MRNA) stands against other firms end 2024 stronger with impressive gains. A lackluster trading persisted throughout the ...

Instead they end in a conserved stem–loop that interacts with stem–loop binding protein (SLBP), a factor involved in several steps of histone mRNA metabolism: pre-mRNA processing, translation ...

Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, ...

在胚胎发育和疾病发展中，RNA修饰已成为调节遗传信息的关键转录后调控因子。最近，5-甲基胞嘧啶(5-methylcytosine，m5C)因其在mRNA代谢中的关键调控作用而受到关注。一般认为，RNA的m5C修饰主要由NOP2/Sun RNA甲基转移酶家族成员2(NSUN2)编辑，NSUN2是参与多种生物过程的 ...

A global international trial of an mRNA vaccine against norovirus is getting underway with the aim of reducing the health burden caused by the infamous “winter vomiting” bug. The trial has ...