发现新的mRNA降解过程 德国巴伐利亚州维尔茨堡大学（JMU）的研究人员现在专注于一种特殊的修饰，n6 -甲基腺苷（m6A）。生物信息学家Kathi Zarnack解释说：“m6A对科学来说是有趣的，因为这种修饰经常在患有代谢紊乱、癌症或心脏病的人身上发生改变。”“ ...

另一方面，YTHDF2 还可以作为 m6A 读取器，通过破坏其他 mRNA 的稳定性来促进免疫逃避，例如抑制 CD19 和 HLA-DMA/B（MHC II类分子）的表达。 YTHDF2促进 ...

"Its function: When m6A is attached to an mRNA, it triggers the degradation of the mRNA as soon as the first proteins have been produced according to the blueprint it contains. This is ...

Research indicates that METTL3 enhances the expression of PD-L1, a protein that helps tumors evade the immune system, through m6A modification of its mRNA[2][3]. This suggests that targeting ...

A team at the University of Würzburg (JMU) in Germany has identified a highly efficient process that breaks down messenger RNA (mRNA) molecules in human cells. This discovery provides insights into a ...

Bioinformatics analysis was performed to explore lncRNA-mRNA networks, leading to the identification of five potential blood biomarkers. Expression analysis was carried out using the GEPIA and GEO ...

The role of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) in cancer has not been well studied. This study reveals a new role of METTL3 in promoting CRC tumour progress through m6A ...