【导读】外转录组修饰，尤其是N6-甲基腺苷（m6A），是基因表达的关键调控因子，影响着RNA的稳定性、剪接和翻译等过程。从Nanopore直接RNA测序（DRS）数据中检测m6A的传统计算方法受限于对实验验证标签的依赖，往往会导致对修饰位点的低估。在 ...

The expression of genes has to be carefully regulated in cells; active genes give cells their identity and ability to function... | Cell And Molecular Biology ...

【导读】N6-甲基腺苷（m6A）修饰在真核细胞中是一种重要的表观遗传调节因子，在肿瘤发生和癌症进展中发挥着重要作用。然而，m6A 调控在胃癌（GC）中的详细生物学功能和潜在机制尚不清楚。1月15日，中山大学陈永明研究团队在期刊《Molecular ...

There have been 67 confirmed human bird flu cases in the U.S. since April 2024. Moderna has been awarded approximately $590 million from the federal government to help speed up the development of ...

甲基化修饰是最常见的RNA修饰之一，包括m6A、m5C、m1A、m7G等，参与RNA稳定性、定位、剪接、翻译 ... m5C MeRIP-seq等 本研究通过视网膜母细胞瘤（RB）细胞和临床样品中的mRNA分离和抗m5C dot blot试验检测全局和mRNA m5C水平。建立原位眼内异种移植模型以检查RB的致癌 ...

A study uncovers how H2O2-induced redox modification regulates the RNA demethylase SlALKBH2. This modification stabilizes SlALKBH2 and accelerates tomato ripening without altering its m6A demethylase ...

Pre-mRNA splicing is carried out by the spliceosome which contains more than 100 proteins ... Funding is available to UK applicants and comprises ‘home’ tuition fees and an annual stipend of £19237 ...

癌症是世界上最难治愈的疾病之一。CAR-T 细胞疗法等一系列癌症免疫疗法的兴起，为癌症治疗带来的新希望。然而，CAR-T 细胞疗法难以持久缓解B细胞恶性肿瘤，这一现象通常可归因于抗原逃逸。例如，CD19 靶向的 CAR-T 细胞疗法中，有 28%-68% 的患者在治疗过程中癌 ...

The 25,000-subject study is testing a nucleoside-modified mRNA (modRNA), quadrivalent vaccine that is targeted against four strains of the flu virus that the World Health Organization (WHO ...