【导读】外转录组修饰，尤其是N6-甲基腺苷（m6A），是基因表达的关键调控因子，影响着RNA的稳定性、剪接和翻译等过程。从Nanopore直接RNA测序（DRS）数据中检测m6A的传统计算方法受限于对实验验证标签的依赖，往往会导致对修饰位点的低估。在 ...

The expression of genes has to be carefully regulated in cells; active genes give cells their identity and ability to function... | Cell And Molecular Biology ...

【导读】N6-甲基腺苷（m6A）修饰在真核细胞中是一种重要的表观遗传调节因子，在肿瘤发生和癌症进展中发挥着重要作用。然而，m6A 调控在胃癌（GC）中的详细生物学功能和潜在机制尚不清楚。1月15日，中山大学陈永明研究团队在期刊《Molecular ...

There have been 67 confirmed human bird flu cases in the U.S. since April 2024. Moderna has been awarded approximately $590 million from the federal government to help speed up the development of ...

Pre-mRNA splicing is carried out by the spliceosome which contains more than 100 proteins ... Funding is available to UK applicants and comprises ‘home’ tuition fees and an annual stipend of £19237 ...

The 25,000-subject study is testing a nucleoside-modified mRNA (modRNA), quadrivalent vaccine that is targeted against four strains of the flu virus that the World Health Organization (WHO ...

表观遗传修饰在多种生物和病理过程中起着关键作用，其中5-甲基胞嘧啶（5mC）被认为是肿瘤发生和进展的早期分子事件，并已成为一个非常有前景的生物标志物。近年来，5-羟甲基胞嘧啶（5hmC）作为5mC的氧化产物，在正常哺乳动物生长和发育中也扮演着重要角色，并与癌症和神经疾病等疾病相关，显示出作为癌症诊断理想生物标志物的巨大潜力。然而，由于5hmC水平比5mC低约14倍，且其结构与C和5mC相似，使得5 ...

RNA is generally single-stranded, as DNA is transcribed by RNA polymerases into mRNA (messenger RNA), which is read by ribosomes to generate protein (translation). Biologically active RNAs ...