【导读】外转录组修饰，尤其是N6-甲基腺苷（m6A），是基因表达的关键调控因子，影响着RNA的稳定性、剪接和翻译等过程。从Nanopore直接RNA测序（DRS）数据中检测m6A的传统计算方法受限于对实验验证标签的依赖，往往会导致对修饰位点的低估。在 ...

singleron-RD/bulk_m6A is a bioinformatics pipeline for processing AccuraCode m6A sequencing data. An extensive list of references for the tools used by the pipeline can be found in the CITATIONS.md ...

RNA modifications like m6A are vital for gene expression but challenging to detect at single-base resolution. Here, the authors introduce pum6a, an advanced computational framework, to enable ...

Michael McWhertor is a journalist with more than 17 years of experience covering video games, technology, movies, TV, and entertainment. So it stands to reason the animated intro may also provide ...

The expression of genes has to be carefully regulated in cells; active genes give cells their identity and ability to function... | Cell And Molecular Biology ...

表观遗传修饰在多种生物和病理过程中起着关键作用，其中5-甲基胞嘧啶（5mC）被认为是肿瘤发生和进展的早期分子事件，并已成为一个非常有前景的生物标志物。近年来，5-羟甲基胞嘧啶（5hmC）作为5mC的氧化产物，在正常哺乳动物生长和发育中也扮演着重要角色，并与癌症和神经疾病等疾病相关，显示出作为癌症诊断理想生物标志物的巨大潜力。然而，由于5hmC水平比5mC低约14倍，且其结构与C和5mC相似，使得5 ...