Following this, TRIzol Reagent (Invitrogen) was utilized for cell lysis. The immunoprecipitation samples contained enrich RNA fragments and input samples were prepared following the protocol from ...

Cancer’s epigenetic landscape, a labyrinthine tapestry of molecular modifications, has long captivated researchers with its profound influence on gene expression and cellular fate. This review ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Chromosome segregation relies on kinetochores ...

表观遗传修饰在多种生物和病理过程中起着关键作用，其中5-甲基胞嘧啶（5mC）被认为是肿瘤发生和进展的早期分子事件，并已成为一个非常有前景的生物标志物。近年来，5-羟甲基胞嘧啶（5hmC）作为5mC的氧化产物，在正常哺乳动物生长和发育中也扮演着重要角色，并与癌症和神经疾病等疾病相关，显示出作为癌症诊断理想生物标志物的巨大潜力。然而，由于5hmC水平比5mC低约14倍，且其结构与C和5mC相似，使得5 ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Mitochondrial carrier homolog 2 (MTCH2) is a ...