E3-ubiquitin ligase inducible degrader of the LDL receptor has a similar function to PCSK9 and is a potential therapeutic target. A desirable treatment target for HoFH patients is LDL-C ≤1.8 mmol/l.

Turmeric (Curcuma longa), a vibrant yellow spice, a rhizomatous herbaceous plant from the ginger family (Zingiberaceae), has ...

Homozygous familial hypercholesterolaemia affects approximately 30 000 individuals worldwide.1,2 Patients have untreated high ...

"Our findings provide a potential new strategy for increasing the ability of the LDL receptor for binding and ... How molecules function is determined by their structures. "When we know their ...

We appreciated the FDA reviewers' alignment with our proposed clinical development program, and their positive feedback on our intended clinical trial design, IND-enabling studies, and drug ...

When it comes to managing cholesterol, the foods we eat can play a significant role in our overall heart health. But there’s ...

NIH scientists visualized how LDL binds to its receptor, identifying mutations causing cholesterol buildup and heart disease. Their findings, published in Nature, could improve personalized treatments ...

Thanks to their amazing nutrient profile, which includes protein, fibre, and antioxidants, walnuts stand out as one of the ...

Altimmune, Inc. (NASDAQ:ALT), a biopharmaceutical company with a market capitalization of $503.56 million focused on ...

Faculty of Medical Technology, Prince of Songkla University, Songkhla 90110, Thailand Division of Biological Science, Faculty of Science, Prince of Songkla University, Songkhla 90110, Thailand ...