Adhesion GPCRs are a group of cell-surface sensors associated with many body functions and diseases. However, they are not yet sufficiently understood to be exploited for therapies.
A recent study has uncovered how specific genetic mutations in α2δ-1 and α2δ-3 proteins linked to autism spectrum disorders (ASD) alter neuronal functionality. These mutations significantly reduce the ...
Researchers have developed a standardized numbering system for adhesion GPCRs, improving knowledge transfer and disease analysis. This AI-driven system, based on 14,000 modelled structures, ...
Bats carry viral pathogens that typically do not lead to severe disease in the bats themselves but can be lethal to humans. Adaptations in certain immune genes might contribute to this resistance.
Adhesion G protein-coupled receptors (GPCRs) are a group of cell-surface sensors associated with many body functions and diseases. However, they are not yet sufficiently understood to be exploited for ...