A recent study suggests that p63 may be key, at least for many epithelial stem cells. As diverse as the coats in a fashion boutique, epithelia are the cellular cloaks of our body and its many organs.

Stem cells can be unipotent, multipotent, pluripotent or totipotent, depending on the number of cell types to which they can give rise. Non-invasive lineage tracing in humans relies on rare ...

Hypoxia-driven gene and protein changes enhance epithelial-to-mesenchymal transition, remodel the extracellular matrix, drive drug resistance, support cancer stem cells and aid evasion from immune ...

To establish mammary organoids, the research team used an approach called curating stem cells to generate organoids of mammary lineage (CUSTOM ... to optimize the process for growing more mammary ...

Using patient tumor tissues, organoids, mouse models, lineage tracing ... factors and recapitulate transcriptional programs in primitive stem cells and regenerative pulmonary epithelial progenitor ...

Plasticity is normal and widespread in the earliest stages of life, as cells mature from embryonic, stem-cell states to ... researchers need "lineage" information—usually based on DNA markers ...

Focusing on epithelial metaplasia ... inflammation-induced alterations in gastrointestinal stem cells generated a distinct metaplastic lineage, termed INFLAREs. These cells, characterized by ...

Mayo Clinic researchers find that stem cells with the highest Myc expression become dominant in driving lung remodeling .

Organoids are 3D cell culture models that more accurately reflect the structural and functional complexities of organs in vitro than traditional 2D cell culture methods. Generally derived from stem ...