Sphere of Influence. In iAssembloids, microglia (red) form projections (white arrows), while astrocytes (green) assume star shapes typically found in the brain. [Courtesy of Kampmann et al., 2025.] ...

A research team have recently published their article, "Rationally designed pooled CRISPRi-seq uncovers an inhibitor of bacterial peptidyl-tRNA hydrolase" in Cell Reports. In this study ...

tuberculosis. Study: Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis. Image Credit ...

CRISPR interference (CRISPRi) is a novel method for specific gene knockdown. It's CRISPR, without the cut. The Horizon CRISPRi system uses a deactivated Cas9 nuclease (dCas9) fused to our proprietary ...

We provide access to CRISPR KO (knockout), CRISPRi (interference) and CRISPRa (activation) technologies, which change the phenotype of cells by eliminating, reducing or increasing gene expression.

Dr. Huangfu is a supportive advocate for career development of her team members. Interested in applying large-scale CRISPR-Cas9 and CRISPRi screens in hPSCs to uncover new aspects of human development ...