Antigen recognition by B cell receptors (BCRs) triggers the initiation of B cell activation and subsequent responses including proliferation and differentiation, leading to the formation of plasma ...

In patients with RCC, exceptional response to immunotherapy may be related to clonal neoantigen-driven cytotoxic T-cell ...

Figure 4: Impaired antigen receptor–activated B cell proliferation and humoral responses in Vav-deficient mice. Figure 5: Vav-2 in BCR signaling and tyrosine phosphorylation in Vav-1 −/− Vav ...

In this advancement, we can identify new chemical entities, pharmacological agents and pharmacophores which influences the receptors mediated cell signalling in diverse cell types. In addition, new ...

For many years the B-cell Immunobiology ... how different B-cell antigen receptor encounters lead to lymphocyte activation, proliferation, or apoptotic deletion. Our lab has shown how in vivo ...

cell- and tissue- specific manner. In the mammalian central nervous system, the atypical ligand Norrin controls angiogenesis and maintenance of the blood-brain barrier and blood-retina barrier through ...

One avenue for this ambition is cell receptors, which function like ignition slots on a cell, requiring keys—such as specific hormones, drugs, or antigens—to start up specific cellular activities.

Signal transduction mechanism of EGFR (epidermal growth factor receptor) transactivation by angiotensin II (AngII) in vascular smooth muscle cells leading to vascular remodeling. Please note that in ...