Because of this flexibility, the 30 to 40 tRNAs present in a cell can "read" all 61 codons in mRNA. The opposite end of the folded structure, which is the 3' end of the tRNA, binds to its ...

Lipids formulated with a bioreducible linker form the wall of nanoparticles encapsulating the mRNA of Cas9 plus sgRNA. Upon entering the cell, in vitro or in vivo, the linkers are broken and the ...

The popularity of mRNA-based therapeutics has surged over the past few years. To ensure the safety of these treatments, scientists need to analyze the characteristics of the manufactured molecules, ...

Translation Begins After the Assembly of a Complex Structure The translation of mRNA begins with the formation of a complex on the mRNA (Figure 4). First, three initiation factor proteins (known ...

RNA breaks destined for repair are inflicted by sequence-specific or structure-specific endoribonucleases during physiological RNA processing (e.g. tRNA splicing; kinetoplast mRNA editing) and under ...