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6 天
12月封面聚焦:肿瘤免疫逃逸,AI预测蛋白结构,PD-L1乳酸化新机制……
上海交通大学医学院附属仁济医院-上海市肿瘤研究所覃文新/王存团队联合复旦大学附属中山医院高强教授团队等在《Cancer Cell》上发表了题为“Targeting the immune privilege of tumor-initiating ...
生物通
6 天
线粒体MT-CO2介导的谷氨酰胺代谢在肿瘤抵抗葡萄糖饥饿中的作用
葡萄糖是肿瘤细胞最重要的能量来源。肿瘤快速生长需消耗大量的葡萄糖,加之肿瘤血管发育不全,导致肿瘤细胞常处于葡萄糖供给不足的“饥饿”状态。研究表明,实体肿瘤组织中的葡萄糖浓度比正常组织低3-10倍。因此,克服葡萄糖饥饿是肿瘤细胞存活和肿瘤生长的关键。肿 ...
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