Malfunction of the p53 pathway is an almost universal hallmark of human tumours. [1,2] Somatic mutation of TP53 that results in the absence or dysfunction of p53 is one of the most common ...

deriving elephant iPSCs proved challenging because these animals have a complex gene pathway not found in other species. The researchers overcame this by suppressing core genes called TP53 that ...

Key mutations were observed in TP53 and ARID1A genes and TP53 pathway was downregulated in patients with primary treatment resistance. A high-risk signature based on the identified molecular ...

This triggered the DNA-damage response (DDR; a signalling pathway that repairs DNA damage and limits the division of cells carrying harmful mutations), subsequent activation of TP53 and elevated ...

To date, no study of a sufficient size has reported a significant association between SNPs at the TP53 locus and altered ... The biological effects of p53 pathway variants at the molecular level ...