In addition to the discovery of human RNA ligases, research has also focused on the mechanisms of tRNA splicing, which is a critical process for the maturation of tRNA molecules. Eukaryotic tRNA ...

Fungal tRNA Splicing as a Paradigm of RNA Repair – Intron-containing tRNAs are widespread in eukarya ... elucidating the unique biochemical requirement for a 2’-PO 4 in the ligation step of ...

The pathogenic mechanism is disruption of developmentally regulated RNA processing, primarily alternative splicing, in which failure to express adult splicing patterns causes primary features of the ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

"By targeting key processes like RNA splicing and modification ... Leslie's powerful and robust model systems to nail down this novel mechanism," said co-corresponding author Robert Spitale ...

By targeting key processes like RNA splicing and modification ... Leslie's powerful and robust model systems to nail down this novel mechanism." The UC Irvine scientists partnered with Clotilde ...

Alternative splicing (AS) is a fundamental regulatory mechanism in messenger RNA (mRNA) processing, and abnormal splicing is a major cause of genetic disorders. To understand the genetic ...

In this webinar, Dr. Megan L Noonan will present her research on the role of alternative splicing in kidney disease progression, discussing how she used nanopore RNA sequencing to accurately detect ...

Role of RNA Splicing in Gynecological Pathologies We recently reported an increase in the ... we are interested in evaluating the underlying molecular mechanism of the functions of autophagy related ...