Fungal tRNA Splicing as a Paradigm of RNA Repair – Intron-containing tRNAs are widespread in eukarya ... elucidating the unique biochemical requirement for a 2’-PO 4 in the ligation step of ...

The pathogenic mechanism is disruption of developmentally regulated RNA processing, primarily alternative splicing, in which failure to express adult splicing patterns causes primary features of the ...

"By targeting key processes like RNA splicing and modification ... Leslie's powerful and robust model systems to nail down this novel mechanism," said co-corresponding author Robert Spitale ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

By targeting key processes like RNA splicing and modification ... Leslie's powerful and robust model systems to nail down this novel mechanism." The UC Irvine scientists partnered with Clotilde ...

A University of California, Irvine-led research team has discovered intricate molecular mechanisms driving the RNA processing defects that lead to Huntington’s disease and link HD with other ...

Role of RNA Splicing in Gynecological Pathologies We recently reported an increase in the ... we are interested in evaluating the underlying molecular mechanism of the functions of autophagy related ...