How do bacteria, lacking a nucleus, organize and pack their genome into the cell? Supercoiling enables this but forces a different kind of transcription and translation in prokaryotes. Aa Aa Aa ...

Researchers have recently discovered that, in eukaryotes, the replication protein A (RPA) is a form of red flag in the cell: when RPA is coating long strands of ssDNA, this signals a checkpoint.

We are interested in the mechanism of chromosome replication, a process that is highly conserved across eukaryotes and that involves the duplication of both the chromosomal DNA and its associated ...