p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

In these cases the nanny is a transcription repressor. High levels of the Hdmx nanny support newly synthesized p53 and p73 accumulation but at the same time inhibit their transcription activity (Fig.

Future Oncol. 2012;8(6):683-686. Collectively, these studies suggest that elevated levels of some p53 isoforms may have favorable prognostic significance, which implies that the extent of function ...

WD-induced MASLD triggered persistent activation of the DNA damage response (DDR) and its primary transcription factor, P53, ...

The aim of the present work was to establish an association between wood smoke exposure and lung cancer pathogenesis, and to analyze the effects of wood smoke on p53 and murine double minute 2 ...