Aa Aa Aa It seems nearly impossible for a normal cell to become a cancer cell unless it inactivates the p53 network. Our current understanding of this network has come from diverse lines of ...

【导读】线粒体氧化磷酸化（OXPHOS）是糖酵解缺陷型癌症的治疗弱点。在这项研究中，团队发现抑制OXPHOS同样能抑制体外和源自患者的CRC异种移植中具有糖酵解能力的结直肠癌（CRC）细胞的增殖和致瘤性。2025年1月14日，澳大利亚纽卡斯尔大学张旭 ...

In evaluating the expression of various genes related to colorectal carcinogenesis, they also observed that, in 71% of the patients who had high levels of oxidative stress, the p53 gene presented ...

Recent research has indicated that ASPP1 is significantly downregulated in colorectal cancer (CRC) cells, which influences p53-mediated apoptotic pathways and facilitates cancer progression (31). In ...

Aims—To investigate the association between immunohistochemical expression of Bcl-2 and p53 in colorectal cancer and tumour recurrence following surgery. Methods—Sixty six cases of Dukes’ B colorectal ...

Conclusions LY2606368 selectively eliminates replication-stressed, p53-deficient and hyperdiploid CRC-SCs independently of RAS mutational ... able to kill a significant fraction (approximately a third ...

Loss of p53 strongly drives the progression of disease from Barrett's to cancer. The team found that potentially cancerous cells that lost both CDKN2A and p53 were weakened and unable to compete ...

In this case, the researchers engineered the tumors to express mutated versions of cancer-linked genes Kras, p53, and APC, which are often found in human colon cancers. Once these tumors were ...

These EVs could be isolated non-invasively from a patient’s body for early diagnosis of cancer. Colon cancer ranks 8th and rectal cancer ranks 9th among men. Annually, cases of colorectal cancer ...

In this case, the researchers engineered the tumors to express mutated versions of cancer-linked genes Kras, p53, and APC, which are often found in human colon cancers. Once these tumors were ...