The authors examine the role of Numb, a Notch inhibitor, in intestinal stem cell self-renewal in Drosophila during homeostasis and regeneration. This is an important study providing evidence of a Numb ...

在日常生活中，吸烟的危害如影随形，时刻威胁着人们的健康。那袅袅升起的烟雾中，隐藏着诸多致病因子，而尼古丁作为香烟的关键成分，更是备受瞩目。你是否想过，它在进入人体后，会在我们的肠道深处悄然引发怎样的“蝴蝶效应”呢？近期Elife的一项重磅研究Nico ...

Here, in bone marrow transplantation and organoid culture models, T-cell-derived Interferon-γ is shown to promote STAT1-dependent intestinal stem cell c-MYC expression and epithelial regeneration.

More information: Jaakko Mattila et al, Stem cell mTOR signaling directs region-specific cell fate decisions during ...