另一方面，为实现疫苗的高效制备，团队还创新性地设计出了系统功能缺陷的工程细胞。通过选择性移除“生命开关”元件 PTD，病毒蛋白得以保留并稳定存在，使得 PROTAR 疫苗可以在疫苗制备细胞中高效复制，满足大量制备的需求。

在这项最新研究中，研究团队发现了一个具有与端粒结合蛋白 TRF1/TRF2 类似的 Myb/SANT-like DNA 结合结构域的新蛋白——MSANTD4（Myb/SANT-like DNA-binding domain-containing ...

Nature Chemical Biology - Chemical biology and systems biology have grown and evolved in parallel during the past decade, but the mindsets of the two disciplines remain quite different. As the ...

本研究率先揭示了HSF1具有温度依赖性相分离特征, ...

Chemical biology is beginning to enhance our understanding ... Many cellular processes are highly dynamic in nature. Endocytosis is known to occur in a matter of minutes. Whereas mutants are ...

2025年1月3日，北京大学、昌平国家实验室邓宏魁课题组与北京大学关景洋课题组合作在国际学术期刊Nature Chemical Biology上发表了题为“A Rapid Chemical Reprogramming System to ...