Researchers at the Crick have uncovered which genes on the Y chromosome regulate the development of sperm and impact ...

Researchers say study represents a resource that could also help to dissect Y-gene functions in other tissues.

Researchers at the Crick have uncovered which genes on the Y chromosome regulate the development of sperm and impact fertility in male mice. This research could help us understand why some men don't ...

1.2.2 Castle, Little, and the founders of mouse genetics The most significant force in early genetic work on the mouse was William Ernest Castle, who directed the Bussey Institute at Harvard ...

As shown in the Timeline, large-scale mouse mutagenesis is divided into three phases. In 1997, ENU mutagenesis began with the use of forward genetics, primarily focusing on dominant phenotypes.

The significance of the interspecific cross for mouse genetics cannot be understated: it was the single most important factor in the development of a whole genome linkage map based on molecular ...

Researchers aim to continue studying the role of the X chromosome in brain aging, and whether it can explain people’s risk of brain diseases or memory loss.

In the new study, the researchers observed that all Dp1Tyb mice—a genetically modified mouse model with an extra copy of a genetic region on mouse chromosome 16 (which mirrors human chromosome 21)—had ...

X inactivation turns off entire chromosomes, whereas imprinting turns ... was not 100% (only 9 of 24 pregnancies resulted in live mouse pups), the level of success was still dramatic considering ...

Protein modifications are key to cell survival because they ensure they do what they are supposed to do in a healthy system.