The popularity of mRNA-based therapeutics has surged over the past few years. To ensure the safety of these treatments, scientists need to analyze the characteristics of the manufactured molecules, ...

The cap structure was later shown to also be required for efficient mRNA processing, export, stabilization and microRNA-mediated gene silencing. These cap functions are mediated by cap-binding ...

Figure 5: Two models for histone variant function in core histone mRNA 3′ end formation ... Their unique 3′ end structure, containing a conserved stem–loop bound by SLBP, is the key feature ...

To add multiple polyA tails to the mRNA backbone and create the branched structure, the scientists used click chemistry ... These results were recapitulated inside a mouse model, where the scientists ...

Why? Researchers at Boston Children’s Hospital, led by Byron Brook, PhD, David Dowling, PhD, and Ofer Levy, MD, PhD, found some answers — while providing proof-of-concept of a new system that can ...

When a gene is to be expressed, the base sequence of DNA is copied or transcribed into mRNA (messenger RNA ... adjacent amino acids to finalise the structure.