These receptors are collectively called 'scavenger ... where it must be transported to the liver and secreted in the bile. Since the function of LDL is to carry cholesterol from the liver to ...

E3-ubiquitin ligase inducible degrader of the LDL receptor has a similar function to PCSK9 and is a potential therapeutic target. A desirable treatment target for HoFH patients is LDL-C ≤1.8 mmol/l.

highlighting the structural basis of defective LDLR function. The study underscores the critical role of LDLR in LDL dimerization and cellular uptake, offering structural insights into receptor ...

Study deciphers the molecular handshake between LDL receptors and apoB100 ... Disruptions in LDLR function or apoB100 mutations, as seen in FH, lead to low-density lipoprotein cholesterol ...

Cholesterol levels are also controlled by a negative feedback system: cells have LDL receptors on their surface which allow cholesterol to be deposited inside the cells by LDLs once there is an ...

In contrast, eNOS is not activated by purified forms of the major HDL apolipoproteins ApoA-I and ApoA-II or by low-density lipoprotein ... reveal that scavenger receptor-BI (SR-BI) mediates ...