A recent study suggests that p63 may be key, at least for many epithelial stem cells. As diverse as the coats in a fashion boutique, epithelia are the cellular cloaks of our body and its many organs.

Stem cells can be unipotent, multipotent, pluripotent or totipotent, depending on the number of cell types to which they can give rise. Non-invasive lineage tracing in humans relies on rare ...

capable of differentiating in vivo and in vitro along the hepatocytic or bile duct epithelial cell (BDEC) lineage. These studies provided the basis for the commonly held view that by ED15 to ED16 ...

Using patient tumor tissues, organoids, mouse models, lineage tracing, advanced imaging ... and lung-specifying transcription factors and recapitulate transcriptional programs in primitive stem cells ...

To establish mammary organoids, the research team used an approach called curating stem cells to generate organoids of mammary lineage (CUSTOM). Since hair follicles and mammary ... The team next ...

Focusing on epithelial metaplasia ... inflammation-induced alterations in gastrointestinal stem cells generated a distinct metaplastic lineage, termed INFLAREs. These cells, characterized by ...