During DNA replication, the unwinding of strands leaves ... effective approach is to find proteins that directly bind to both enzymes. However, that requires us to understand the molecular ...

Cells employ an arsenal of editing mechanisms to correct mistakes made during DNA replication. How do they work, and what happens when these systems fail?

Free DNA nucleotides – needed to form the new strands. DNA polymerase – an enzyme that adds new nucleotides to a growing strand of DNA. Primers – A primer is a short strand of nucleotides th ...

APOBEC enzymes, which normally help fight viral infections by mutating viral DNA, cause repeat expansions and are unusually ...

DNA replication is the process by which the DNA molecule makes an exact copy of itself during cell division. The double helix unwinds, and each strand serves as a template for the synthesis of a new ...

The repair enzymes are remarkably conserved from bacteria to fungi to humans, underscoring the premium placed on maintaining genomic integrity in the face of a mutagenic burden. DNA is susceptible to ...

Actually, that's DNA's main purpose: to make proteins within the cell. These proteins, which include enzymes that do specialized jobs, control the activities of the cell. Different cells have ...

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous ... essentially the ...

T cells play a pivotal role in the immune system by transforming into powerful effector cells that combat pathogens. This transformation requires rapid proliferation, during which DNA replication ...

The following is a summary of “Cobalt chloride-mimicked hepatocyte cell hypoxia induces TREX1 leading to Hepatitis B virus restriction,” published in the January 2025 issue of Infectious Disease by ...