The company has developed a suite of functional genomic screening ... KO (knockout), CRISPRi (interference) and CRISPRa (activation) technologies, which change the phenotype of cells by ...

Horizon develops genetically engineered cell models using ... the provision of comprehensive screening services, including whole genome CRISPRko, CRISPRa and CRISPRi screening.

Sphere of Influence. In iAssembloids, microglia (red) form projections (white arrows), while astrocytes (green) assume star shapes typically found in the brain. [Courtesy of Kampmann et al., 2025.] ...

We apply both precision gene editing and large-scale CRISPR screening in human pluripotent stem cells (hPSCs ... Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear ...

tuberculosis. Study: Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis. Image Credit ...

2002). The result is a broadly functional repressor, turning gene expression down but not off. CRISPRi dCas9-SALL1-SDS3 is available as mRNA for transient expression or in lentiviral particles for ...

Interested in applying large-scale CRISPR-Cas9 and CRISPRi screens in hPSCs to uncover new aspects of human development and disease ... The project will involve directed differentiation of pluripotent ...

UC Santa Cruz researchers have discovered a peptide in human RNA that regulates ... high-throughput screening to rapidly identify functional lncRNAs in immune cells. The pooled-screen approach ...