The concept of 'checkpoints' arose from the discovery of genes in budding yeast that are required for coordinating the progression of cell-cycle events when earlier processes have not been ...

Many genes involved in cell motility and remodeling of ... both of which cause DNA damage and consequent cell-cycle arrest at multiple checkpoints. DNA-damage experiments were performed in ...

Proliferating animal cells maintain a stable size distribution over generations despite fluctuations in cell growth and division size. Previously, we showed that cell size control involves both cell ...

This exhaustion is influenced by immune checkpoint receptors, which are inhibitory cell surface receptors that can suppress antitumor immunity. Notably, intracellular checkpoint molecules within ...

A review discussing the therapeutic potentials of NK cell biology has been published in the journal Frontiers of Medicine. Natural killer (NK) cells are pivotal in the innate immune response ...

Checkpoint activation results in the stabilization of stalled forks, prevents further origin firing, and creates a cellular milieu that promotes the resolution of replication fork blocks before entry ...