Amanitin is now filling that gap through the inhibition of RNA polymerase II. Whilst the compound is toxic to the liver, Heidelberg Pharma’s proprietary Antibody Targeted Amanitin Conjugate ...

For instance, bacteria contain a single type of RNA polymerase, while eukaryotes ... RNA pol II is uniquely sensitive to amatoxins, such as a-amanitin of the extremely toxic Amanita genus of ...