Here, Artandi and DePinho discuss how studies in mice have uncovered a complex interplay between the ARF-p53 pathway, genomic instability due to telomere dysfunction, and the suppression or ...

p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

Usually found at low levels in cells, the p14 Alternative Reading Frame protein (p14 ARF) is expressed at higher levels under ...

Usually found at low levels in cells, the p14 Alternative Reading Frame protein (p14 ARF) is expressed at higher levels under oncogenic stress and activates p53. The researchers identified an ...